Kinnate Biopharma Inc. to Present Pre-Clinical Data from its RAF Kinase Inhibitor Program at Annual ASCO Meeting
Data highlights pre-clinical activity of KIN-2787 in Class II and Class III BRAF-mutant models
“As we advance towards the initiation of clinical studies for our lead RAF inhibitor program, we are honored to be selected by the ASCO Scientific Program Committee to present findings from our pre-clinical studies of KIN-2787 at this year’s Annual Meeting,” said
Oncogenic BRAF gene alterations, leading to aberrantly activated BRAF monomers (Class I mutations) or dimers (Class II and Class III mutations), are observed in approximately 6% of all human cancers. First-generation BRAF inhibitors targeting Class I BRAF mutants, including dabrafenib, encorafenib, and vemurafenib, provide significant clinical benefit to patients with BRAF V600 mutation-driven melanoma and select solid tumors as monotherapies or in combination with other targeted therapies. The currently approved BRAF inhibitors have not, however, proven to be effective in patients with Class II or III BRAF alterations. For example, approximately 62% of BRAF mutations in non-small-cell lung carcinoma (NSCLC) and approximately 21% of BRAF mutations in melanoma are identified as Class II and Class III BRAF mutations where the currently approved Class I inhibitors are not effective.
The data to be presented at the ASCO annual meeting were derived from pre-clinical studies evaluating the efficacy and tolerability of KIN-2787 in vitro and in vivo in BRAF mutation-driven human cancer models. A phase 1 dose escalation and expansion clinical trial evaluating the safety and efficacy of KIN-2787 monotherapy in patients with advanced or metastatic solid tumors harboring BRAF gene alterations, including Class II and III mutations, is expected to initiate in 2021.
Additional information on the ASCO annual meeting can be found online at: https://meetings.asco.org. Per ASCO’s Embargo & Release Information, complete abstracts will be released to the public on ASCO’s
Kinnate’s poster presentation will become available for on-demand viewing beginning
Kinnate is focused on the discovery and development of small molecule kinase inhibitors for difficult-to-treat, genomically defined cancers. Kinnate’s mission is to expand the reach of targeted therapeutics by developing products for underserved populations. Kinnate utilizes its deep expertise in structure-based drug discovery, translational research, and patient-driven precision medicine, which it refers to as the Kinnate Discovery Engine, to develop targeted therapies. Based in
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